We like to / prefer to use Zencart E-Commerce Solutions.
For the basic user it is an interface that someone can learn easily and modify the layout of their web store with ease.
It has many many 3rd party templates and plugins that allow your site the flexability of the bigs ones however on a budget.
We here at SCOM can assist you on setup and so forth
Because we fully support Zencart we have already built in daily backups and many other authmated services that ensure your site stays up 24/7
Please feel free to contact us further for more information.